Equipment

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          M2™ Compact High-Performance MRI (1 T)    
          Optical Imaging
          PET/CT 
          Ultrasound 

M2™ Compact High-Performance MRI (1 T)

Aspect's M2™ platform and suite of products enables academic researchers and pharmaceutical companies to harness the power and insights of MRI but without the cost, complexity and technical burden of traditional MRI systems. With Aspect’s integrated and simple-to-use platform, researchers can derive deep insights into their biological questions quickly, easily and cost-effectively with the push of a button. The system has no fringe magnetic field, therefore the M2 can be placed anywhere in a working lab including at a scientist’s benchtop.

The M2™ platform is used by leading institutions for a broad range of in vivo, ex vivo and in vitro applications including high-resolution 3D anatomical, molecular, functional and multi-modality imaging. The Aspect high-performance MRI system is used to quantify the expression of disease, to monitor disease progression and to assess therapeutic efficacy and response.

Aspect Imaging
 

 

 User Manuals

Optical Imaging

In-Vivo  MS FX PRO (Carestream Molecular Imaging)
The Carestream In Vivo MS FX PRO® system is designed for researchers who need to image and monitor pathologies within small animals using optical probes and radioactive probes in 2D.  Multiple mice or rats can be imaged simultaneously.  The system can image small animal models using any combination of fluorescence, luminescence, radio-isotopic and radiographic imaging modalities.  The system comes with a high resolution X-ray system capable of generating high resolution X-ray for co-registering optical signals to anatomical landmarks as well as tracking and quantifying changes in bone and soft tissue.  This system also provides researchers an advanced methodology for the removal of non-specific autofluorescence excitation based spectral deconvolution. This software can also be utilized to image multiple fluorescent probes simultaneously.  These optical imaging modalities are most often used for tumor and stem cell tracking, imaging enzyme activity with activatable probes, inflammation imaging, and cell death imaging.  Researchers developing novel optical probes including peptides, antibodies and nanoparticles can also utilize this instrument to rapidly validate the targeting and specificity of their probes.  For researchers designing translatable probes the MS FX PRO can serve as a pre- screening tool prior to imaging on the Albira PET/CT using the radio-isotopic screen or by leveraging multi functional fluorescence and radio-isotopic probes and biomarkers.
 

 

User Manuals

IVIS 100 (currently out of service)  (Caliper Life Sciences, formerly Xenogen) The IVIS 100 is a sensitive and large field of view imaging system. The IVIS 100 offers an adjustable field of view of 10 – 25 cm, allowing 5 mice or 2 large rats to be imaged. The system features a 25 mm (1.0 inch) square back-thinned, back-illuminated CCD, which is cooled to -90 °C via a closed system to minimize electronic background and maximize sensitivity. An extremely light tight, low background imaging chamber allows the IVIS 100 to be used in standard lab lighting environments.

The system includes animal handling features such as a heated sample shelf, gas anesthesia connections, and an optional full anesthesia system.

The IVIS 100 is highly automated with all hardware motor movement, imaging parameters, and image analysis controlled via Living Image software. Specialized Living Image software from Caliper controls the imaging process as well as image acquisition and analysis.

 

Photos (from vendor website)
 

 

PET/CT

Albira® PET/CT (Carestream Molecular Imaging)
The Carestream Albira® PET/CT provides two powerful imaging modalities for pre-clinical in vivo molecular imaging.  These capabilities include Positron Emission Tomography (PET) and X-ray Computed Tomography (CT).  The state-of-the-art detector system consists of continuous crystals coupled to PSMPTs and advanced PET detector electronics.  This PET and CT are ideally suited for quantitative 3D imaging in small animal models such as mice and rats.  The system is a fully shielded cabinet X-ray system to provide users the safest working environment.  Researchers can utilize the Albira system for both static and dynamic PET acquisitions which are automatically co-registered with CT for anatomical localization of functional imaging data.  Because the animal is not harmed during the study, researchers can conduct longitudinal studies in oncology, neuroscience, metabolic, and bone diseases.  For researchers interested in developing and validating translational reporters and probes, this system offers an opportunity to study and validate their probes in vivo using PET tracers which are much more readily translatable to clinical environments than optical probes.
 

 

User Manuals

Ultrasound

Vevo® 2100 System (VisualSonics)
The VisualSonics Vevo® 2100 is a system with expanded functionality, flexibility and image quality, and operating at frequencies never before achieved with solid-state array transducers. The imaging and processing options include Color and Power Doppler Modes for blood flow quantification & anatomical identification; M-Mode single line acquisition allowing high-temporal resolution for LV functional analysis; anatomical M-Mode for adjustable anatomical orientation in reconstructed M-Mode imaging; 3D-Mode Imaging & volume analysis; nonlinear contrast imaging and advanced measurements & quantification. The new MicroScan™ transducers provide increased frame rates, superb contrast, unrivaled resolution and a wider field of view. The system is easy to use, non-invasive and fast, providing extremely high throughput when needed. The Vevo high-resolution in vivo micro-imaging systems provides high-resolution imaging down to 30 microns and the ability to easily export derived statistical data to any computer for analysis. All areas of research involving phenotypic expression within the small animal model can apply the high-resolution, real-time visualization benefits of this system. This includes cardiovascular, cancer biology, neurobioloby, gene delivery, nephrology, regenerative medicine, contrast imaging, image-guided injection and 3D visualization and measurement etc.  Vevo 2100 is a redefined state-of-the-art system with a new digital platform delivering outstanding performance in a wide range of applications and animal models.
 

 

User Manual

Micro CT   

Bruker Skyscan 1172 Micro-CT (Bruker)

What Can it Do?

  • Non-destructive 3-D imaging
  • Any x-ray attenuating material
  • So far, our users have scanned bone, kidney and bladder stones, biomaterial lattice and mineralizing lattice explants, lactose powder, spinal cord, flowers
  • Soft tissue or other poorly absorbing material may require contrast agent
  • Sample size:
    • Maximum diameter 35 mm
    • Maximum height 80 mm
    • 5 micron resolution; 1 micron detectability

How Does it Work?

  • Similar to human clinical CT
  • However, in this case the sample turns within the path of the x-ray beam

MicroCT is Non-Destructive

  • Bone shown previously can be further processed by strength testing or by classical histochemistry
  • As shown on the bladder stone slide, images correlate with classical 2-D x-ray and with subsequent histology

Soft Tissue Imaging

  • Soft tissues can be imaged with the help of contrast agents such as polyfil
  • In a trial of imaging at 5 µm resolution of spinal cord from a rat with induced injury, it was possible to distinguish white and grey matter in the cord!
  • Imaging is not restricted to small animal tissues - anything that will absorb x-rays and is small enough to fit in the scanner can be imaged
  • Synthetic materials, plant materials, soil samples, rocks, small tools or tool parts, fossils are just some of the items that have been scanned by microCT